USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

USC-OGP 2-DE database  Search by                Maps             Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal World-2DPAGE Repository Exclude local DBs has only effect if a remote interface is selected

Searching in 'USC-OGP 2-DE database' for entry matching: Q13418 USC-OGP 2-DE database:  Q13418 Q13418 General information about the entry View entry in simple text format Entry name ILK_HUMAN Primary accession number Q13418 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Integrin-linked protein kinase; EC=2.7.11.1; AltName: Full=59 kDa serine/threonine-protein kinase; AltName: Full=ILK-1; AltName: Full=ILK-2; AltName: Full=p59ILK;. Gene name Name=ILK Synonyms=ILK1, ILK2 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_6-11 {PLATELET 6-11} Homo sapiens (Human)   map experimental info   PLATELET_6-11 MAP LOCATIONS: SPOT OGP-0914: pI=7.45; Mw=49883 Cross-references UniProtKB/Swiss-Prot Q13418; ILK_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name ILK_HUMAN Primary accession number Q13418 Secondary accession number(s) B7Z1I0 B7Z418 D3DQU0 P57043 Q68DZ3 Sequence was last modified on  August 1, 1998 (version 2) Annotations were last modified on  March 15, 2017 (version 186) Name and origin of the protein Description RecName: Full=Integrin-linked protein kinase; EC=2.7.11.1; AltName: Full=59 kDa serine/threonine-protein kinase; AltName: Full=ILK-1; AltName: Full=ILK-2; AltName: Full=p59ILK; Gene name Name=ILK Synonyms=ILK1, ILK2 Encoded on Name=ILK; Synonyms=ILK1, ILK2 Keywords 3D-structure; Acetylation; Alternative splicing; ANK repeat; ATP-binding; Cell junction; Cell membrane; Cell projection; Complete proteome; Cytoplasm; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL U40282; AAC16892.1; -; mRNA EMBL AJ277481; CAB94832.1; ALT_SEQ; mRNA EMBL AF244139; AAF74449.1; -; Genomic_DNA EMBL AJ404847; CAB99253.1; -; Genomic_DNA EMBL AK293474; BAH11516.1; -; mRNA EMBL AK296628; BAH12404.1; -; mRNA EMBL CR407673; CAG28601.1; -; mRNA EMBL CR749220; CAH18077.1; -; mRNA EMBL AC091564; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL CH471064; EAW68688.1; -; Genomic_DNA EMBL CH471064; EAW68689.1; -; Genomic_DNA EMBL CH471064; EAW68690.1; -; Genomic_DNA EMBL BC001554; AAH01554.1; -; mRNA CCDS CCDS60712.1; -. [Q13418-2]; . CCDS CCDS60713.1; -. [Q13418-3]; . CCDS CCDS7768.1; -. [Q13418-1]; . PIR S68455; S68455; . RefSeq NP_001014794.1; NM_001014794.2. [Q13418-1]; . RefSeq NP_001014795.1; NM_001014795.2. [Q13418-1]; . RefSeq NP_001265370.1; NM_001278441.1. [Q13418-2]; . RefSeq NP_001265371.1; NM_001278442.1. [Q13418-3]; . RefSeq NP_004508.1; NM_004517.3. [Q13418-1]; . RefSeq XP_005252961.1; XM_005252904.4. [Q13418-1]; . RefSeq XP_005252962.1; XM_005252905.2. [Q13418-3]; . RefSeq XP_011518367.1; XM_011520065.1. [Q13418-1]; . UniGene Hs.706355; -; . PDB 2KBX; NMR; -; A=1-171 PDB 3F6Q; X-ray; 1.60 A; A=1-170 PDB 3IXE; X-ray; 1.90 A; A=1-174 PDB 3KMU; X-ray; 1.80 A; A=183-452 PDB 3KMW; X-ray; 2.00 A; A=183-452 PDB 3REP; X-ray; 1.80 A; A=183-452 PDB 4HI8; X-ray; 1.20 A; A=1-174 PDB 4HI9; X-ray; 1.20 A; A=1-174 PDBsum 2KBX; -; . PDBsum 3F6Q; -; . PDBsum 3IXE; -; . PDBsum 3KMU; -; . PDBsum 3KMW; -; . PDBsum 3REP; -; . PDBsum 4HI8; -; . PDBsum 4HI9; -; . ProteinModelPortal Q13418; -; . SMR Q13418; -; . BioGrid 109824; 214; . DIP DIP-38657N; -; . IntAct Q13418; 178; . MINT MINT-1465247; -; . STRING 9606.ENSP00000299421; -; . BindingDB Q13418; -; . ChEMBL CHEMBL5247; -; . GuidetoPHARMACOLOGY 2041; -; . iPTMnet Q13418; -; . PhosphoSitePlus Q13418; -; . SwissPalm Q13418; -; . DMDM 9973397; -; . OGP Q13418; -; . EPD Q13418; -; . PaxDb Q13418; -; . PeptideAtlas Q13418; -; . PRIDE Q13418; -; . DNASU 3611; -; . Ensembl ENST00000299421; ENSP00000299421; ENSG00000166333. [Q13418-1]; . Ensembl ENST00000396751; ENSP00000379975; ENSG00000166333. [Q13418-1]; . Ensembl ENST00000420936; ENSP00000403487; ENSG00000166333. [Q13418-1]; . Ensembl ENST00000528995; ENSP00000435323; ENSG00000166333. [Q13418-2]; . Ensembl ENST00000532063; ENSP00000434492; ENSG00000166333. [Q13418-3]; . GeneID 3611; -; . KEGG hsa:3611; -; . UCSC uc010rap.3; human. [Q13418-1]; . CTD 3611; -; . DisGeNET 3611; -; . GeneCards ILK; -; . HGNC HGNC:6040; ILK; . HPA CAB004041; -; . HPA HPA048437; -; . MIM 602366; gene; . neXtProt NX_Q13418; -; . OpenTargets ENSG00000166333; -; . PharmGKB PA29855; -; . eggNOG KOG0195; Eukaryota; . eggNOG COG0666; LUCA; . GeneTree ENSGT00760000118807; -; . HOGENOM HOG000047828; -; . HOVERGEN HBG002437; -; . InParanoid Q13418; -; . KO K06272; -; . PhylomeDB Q13418; -; . TreeFam TF315194; -; . BRENDA 2.7.10.2; 2681; . Reactome R-HSA-446343; Localization of the PINCH-ILK-PARVIN complex to focal adhesions; . Reactome R-HSA-446353; Cell-extracellular matrix interactions; . SignaLink Q13418; -; . SIGNOR Q13418; -; . ChiTaRS ILK; human; . EvolutionaryTrace Q13418; -; . GeneWiki Integrin-linked_kinase; -; . GenomeRNAi 3611; -; . PRO PR:Q13418; -; . Proteomes UP000005640; Chromosome 11; . Bgee ENSG00000166333; -; . CleanEx HS_ILK; -; . ExpressionAtlas Q13418; baseline and differential; . Genevisible Q13418; HS; . GO GO:0030054; C:cell junction; IDA:HPA; . GO GO:0005911; C:cell-cell junction; IEA:Ensembl; . GO GO:0043034; C:costamere; IEA:Ensembl; . GO GO:0005737; C:cytoplasm; IBA:GO_Central; . GO GO:0005829; C:cytosol; IDA:HPA; . GO GO:0043198; C:dendritic shaft; IEA:Ensembl; . GO GO:0005925; C:focal adhesion; IDA:UniProtKB; . GO GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell; . GO GO:0016020; C:membrane; IDA:UniProtKB; . GO GO:0043025; C:neuronal cell body; IEA:Ensembl; . GO GO:0005654; C:nucleoplasm; IDA:HPA; . GO GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell; . GO GO:0043234; C:protein complex; IEA:Ensembl; . GO GO:0030017; C:sarcomere; IEA:UniProtKB-SubCell; . GO GO:0001725; C:stress fiber; IEA:Ensembl; . GO GO:0043195; C:terminal bouton; IEA:Ensembl; . GO GO:0005524; F:ATP binding; IEA:UniProtKB-KW; . GO GO:0019901; F:protein kinase binding; IPI:UniProtKB; . GO GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB; . GO GO:0004871; F:signal transducer activity; IBA:GO_Central; . GO GO:0001658; P:branching involved in ureteric bud morphogenesis; IEA:Ensembl; . GO GO:0007569; P:cell aging; IEA:Ensembl; . GO GO:0007050; P:cell cycle arrest; IEA:Ensembl; . GO GO:0034329; P:cell junction assembly; TAS:Reactome; . GO GO:0008283; P:cell proliferation; NAS:UniProtKB; . GO GO:0007160; P:cell-matrix adhesion; TAS:ProtInc; . GO GO:0045197; P:establishment or maintenance of epithelial cell apical/basal polarity; IEA:Ensembl; . GO GO:0010761; P:fibroblast migration; IEA:Ensembl; . GO GO:0007229; P:integrin-mediated signaling pathway; IDA:MGI; . GO GO:0000165; P:MAPK cascade; IBA:GO_Central; . GO GO:0007275; P:multicellular organism development; IBA:GO_Central; . GO GO:0032288; P:myelin assembly; IEA:Ensembl; . GO GO:0022011; P:myelination in peripheral nervous system; IEA:Ensembl; . GO GO:0010667; P:negative regulation of cardiac muscle cell apoptotic process; IEA:Ensembl; . GO GO:2000178; P:negative regulation of neural precursor cell proliferation; IEA:Ensembl; . GO GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Ensembl; . GO GO:0006469; P:negative regulation of protein kinase activity; IEA:Ensembl; . GO GO:0014912; P:negative regulation of smooth muscle cell migration; IEA:Ensembl; . GO GO:0048662; P:negative regulation of smooth muscle cell proliferation; IEA:Ensembl; . GO GO:0021675; P:nerve development; IEA:Ensembl; . GO GO:0048812; P:neuron projection morphogenesis; IEA:Ensembl; . GO GO:0003151; P:outflow tract morphogenesis; IEA:Ensembl; . GO GO:0018105; P:peptidyl-serine phosphorylation; IEA:Ensembl; . GO GO:0070527; P:platelet aggregation; IMP:UniProtKB; . GO GO:0045773; P:positive regulation of axon extension; IEA:Ensembl; . GO GO:0030513; P:positive regulation of BMP signaling pathway; IEA:Ensembl; . GO GO:0090263; P:positive regulation of canonical Wnt signaling pathway; IMP:UniProtKB; . GO GO:0030335; P:positive regulation of cell migration; IEA:Ensembl; . GO GO:0008284; P:positive regulation of cell proliferation; IEA:Ensembl; . GO GO:0001954; P:positive regulation of cell-matrix adhesion; IEA:Ensembl; . GO GO:0050775; P:positive regulation of dendrite morphogenesis; IEA:Ensembl; . GO GO:0043406; P:positive regulation of MAP kinase activity; IEA:Ensembl; . GO GO:0045663; P:positive regulation of myoblast differentiation; IEA:Ensembl; . GO GO:0045669; P:positive regulation of osteoblast differentiation; IEA:Ensembl; . GO GO:0042327; P:positive regulation of phosphorylation; IMP:UniProtKB; . GO GO:0051897; P:positive regulation of protein kinase B signaling; IEA:Ensembl; . GO GO:0045893; P:positive regulation of transcription; DNA-templated; IMP:UniProtKB GO GO:0051291; P:protein heterooligomerization; IEA:Ensembl; . GO GO:0043491; P:protein kinase B signaling; IEA:Ensembl; . GO GO:0006468; P:protein phosphorylation; IDA:UniProtKB; . GO GO:0032956; P:regulation of actin cytoskeleton organization; IEA:Ensembl; . GO GO:0034446; P:substrate adhesion-dependent cell spreading; IMP:UniProtKB; . GO GO:0097435; P:supramolecular fiber organization; IEA:Ensembl; . Gene3D 1.25.40.20; -; 2; . InterPro IPR002110; Ankyrin_rpt; . InterPro IPR020683; Ankyrin_rpt-contain_dom; . InterPro IPR011009; Kinase-like_dom; . InterPro IPR000719; Prot_kinase_dom; . InterPro IPR001245; Ser-Thr/Tyr_kinase_cat_dom; . Pfam PF12796; Ank_2; 2; . Pfam PF07714; Pkinase_Tyr; 1; . SMART SM00248; ANK; 3; . SUPFAM SSF48403; SSF48403; 1; . SUPFAM SSF56112; SSF56112; 1; . PROSITE PS50297; ANK_REP_REGION; 1; . PROSITE PS50088; ANK_REPEAT; 3; . PROSITE PS50011; PROTEIN_KINASE_DOM; 1; .

Gateways to other related servers

• The World-2DPAGE Constellation - Entry point to the world-wide 2-DPAGE resources.
• World-2DPAGE Repository - A public repository for gel-based proteomics data linked to protein identification published in the literature.
• World-2DPAGE Portal - A dynamic portal to query simultaneously world-wide gel-based proteomics databases.
• SWISS-2DPAGE - The Geneva Two-dimensional polyacrylamide gel electrophoresis database.
• ExPASy - The resources web server of the Swiss Institute of Bioinformatics

[Home]